Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Linear Differential Equations01:27

Linear Differential Equations

96
The integrating factor method provides a systematic way to solve first-order linear differential equations, especially those that cannot be handled by separation of variables. This method is particularly useful in modeling time-dependent physical systems influenced by both constant inputs and resistive forces. A common example is the motion of a car subjected to a constant engine force while experiencing air resistance proportional to its velocity.In such scenarios, Newton’s second law...
96
Principle of Linear Impulse and Momentum for a Single Particle01:20

Principle of Linear Impulse and Momentum for a Single Particle

1.6K
Linear momentum is a fundamental concept in physics that describes the motion of an object. It is a vector quantity, having a magnitude equal to the product of its mass and its velocity, and direction along the object's velocity. On the other hand, linear impulse, also known as momentum impulse, is a concept in physics related to the change in the linear momentum of an object. Impulse is a vector quantity defined as the product of force and the time over which the force is applied.
Delving...
1.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Principle of Linear Impulse and Momentum for a Single Particle: Problem Solving01:23

Principle of Linear Impulse and Momentum for a Single Particle: Problem Solving

1.1K
Consider a wooden box and a cylinder of known masses m1 and m2, respectively,  hanging from a ceiling with the help of a massless pulley system.
1.1K
Modeling with Differential Equations01:25

Modeling with Differential Equations

89
Population dynamics can be described mathematically by considering the population size P(t) as a function of time. The rate of change of the population is then represented by the derivative of P(t). A simple assumption is that the rate of growth is proportional to the size of the population itself. This leads to an exponential growth model, where the population increases rapidly without bound. While this is a useful first approximation, it does not reflect realistic long-term...
89
Linear Circuits01:17

Linear Circuits

878
A linear circuit is characterized by its output having a direct proportionality to its input, adhering to the linearity property, which encompasses the principles of homogeneity (scaling) and additivity. Homogeneity dictates that when the input, also referred to as the excitation, is multiplied by a constant factor, the output, known as the response, is correspondingly scaled by the same constant factor. For instance, if the current is multiplied by a constant 'k,' the voltage likewise...
878

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Metabolomic Signatures of Relapse and Survival in AML Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation.

Hematology reports·2026
Same author

Design, Synthesis, and Biological Evaluation of Novel Cyclopenta[<i>c</i>]chromene Derivatives Containing a Cinnamate Skeleton.

Journal of agricultural and food chemistry·2026
Same author

Generating high-quality porcine iPSCs with the new medium cocktail LACID.

Stem cell reports·2026
Same author

In vitro mimicking of humanized cardiogenesis under porcine condition.

Cell & bioscience·2026
Same author

Tutorial: annotation of animal genomes.

Nature protocols·2026
Same author

Glioblastoma stem cells show transcriptionally correlated spatial organization.

Communications biology·2026
Same journal

Plasmonic nanocomposite helices for weather-adaptive LiDAR function.

Nature communications·2026
Same journal

Multidirectional strain-insensitive stretchable RF electronics.

Nature communications·2026
Same journal

In-scanner thoughts contribute to resting-state functional connectivity.

Nature communications·2026
Same journal

Metal-center electron affinity modulates multicolor electrochromism in 2D conjugated metal-organic frameworks.

Nature communications·2026
Same journal

Hyperbranched dielectric polymer networks exhibiting giant energy storage density at 250 °C.

Nature communications·2026
Same journal

3D nanoprinting of metals by spatiotemporally confined hot electrons via multiple-electron excitations in nanocrystals.

Nature communications·2026
查看所有相关文章
  1. 首页
  2. Flash-mm:使用线性混合效应模型进行快速和可扩展的单细胞差异表达分析.
  1. 首页
  2. Flash-mm:使用线性混合效应模型进行快速和可扩展的单细胞差异表达分析.

相关实验视频

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.8K

FLASH-MM:使用线性混合效应模型进行快速和可扩展的单细胞差异表达分析.

Changjiang Xu1, Delaram Pouyabahar1,2, Veronique Voisin3

  • 1The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

Nature communications
|February 5, 2026

在PubMed 上查看摘要

概括
此摘要是机器生成的。

我们开发了FLASH-MM,这是用于单细胞微分表达式分析的快速和可扩展的算法. 这种方法准确地识别基因表达变化,同时提高大数据集的计算效率.

更多相关视频

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
08:13

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

Published on: May 31, 2021

3.7K
Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
11:17

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

Published on: January 18, 2020

10.9K

相关实验视频

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.8K
A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish
08:13

A Scalable Model to Study the Effects of Blunt-Force Injury in Adult Zebrafish

Published on: May 31, 2021

3.7K
Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
11:17

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells

Published on: January 18, 2020

10.9K

科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 单细胞RNA测序 (scRNA-seq) 提供了高分辨率的基因表达数据.
  • 对差异基因表达的scRNA-seq数据的分析在可扩展性,样本相关性和个体变异方面提出了挑战.

研究的目的:

  • 为单细胞微分表达分析开发一种快速且可扩展的算法.
  • 为了解决计算复杂性和内存使用在线性混合效应模型 (LMM) 对scRNA-seq数据的估计.

主要方法:

  • 开发了FLASH-MM,这是一种用于线性混合效应模型 (LMM) 的新型估计算法.
  • 改进了LMM估计程序,以提高计算速度和减少内存需求.
  • 使用模拟的scRNA-seq数据和真实世界的数据集 (结核病免疫细胞,细胞) 验证了算法.

主要成果:

  • FLASH-MM在微分表达式分析中展示了准确性和计算效率.
  • 该算法有效地控制了假阳性率,并保持了高的统计能力.
  • 在各种生物环境中,FLASH-MM显著加速单细胞差异表达分析.

结论:

  • FLASH-MM为分析大规模scRNA-seq数据提供了一种强大而高效的解决方案.
  • 该算法的速度和准确性使其对各种生物应用具有价值.
  • 在单细胞研究中,FLASH-MM促进了强大的差异基因表达分析.