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相关概念视频

Spinal Nerves: Plexus II01:21

Spinal Nerves: Plexus II

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The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
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Spinal Nerves: Anatomy01:23

Spinal Nerves: Anatomy

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Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
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Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
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Morphogenesis02:19

Morphogenesis

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Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
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Binet's Contribution to Measures of Intelligence01:23

Binet's Contribution to Measures of Intelligence

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Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
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Wechsler's Contribution to Measures of Intelligence01:23

Wechsler's Contribution to Measures of Intelligence

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David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
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相关实验视频

Updated: Feb 10, 2026

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
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Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

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素N在发育过程中促进脊柱运动神经的形态发生.

Charles G Marcucci, Marieke Jones, Coleman Blanton

    bioRxiv : the preprint server for biology
    |February 9, 2026
    PubMed
    概括

    纳素-n (Tnn) 是一种细胞外基质蛋白,对于斑马鱼的脊柱运动神经发育至关重要. 失去Tnn会导致轻微的运动轴突引导缺陷,揭示其在神经组合中的作用.

    科学领域:

    • 神经科学是一个神经科学.
    • 发展生物学 发展生物学
    • 分子生物学分子生物学

    背景情况:

    • 脊柱运动神经的发育涉及神经元,神经和肌肉之间的复杂相互作用.
    • 细胞外基质 (ECM) 蛋白对于神经组合至关重要,但它们的具体作用尚未完全理解.
    • 纳-n (Tnn) 是一种ECM糖蛋白,在神经发育中功能定义不佳.

    研究的目的:

    • 为了研究田素-n (Tnn) 在斑马鱼脊柱运动神经发育中的作用.
    • 阐明Tnn在运动轴突指导和神经形态发生过程中的作用.

    主要方法:

    • 利用现场杂交和免疫组织化学来确定Tnn表达模式.
    • 产生了一个CRISPR/Cas9突变等位基因 (tnn uva96) 来研究Tnn功能.
    • 在野生类型和突变斑马鱼中进行了运动神经发育的体内成像和形态分析.

    主要成果:

    • 在脊髓运动神经发育过程中,Tnn在垂直神经管和腹部神经管上表达.
    • 丧失Tnn功能导致异位运动轴突的暂时增加.
    • 在缺少Tnn.的斑马鱼体内观察到异常的运动轴突分支.

    结论:

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    • 纳素-n (Tnn) 在脊柱运动神经组合中起到以前未知的作用.
    • Tnn有助于运动轴突的精确指导和形态发生.
    • 这项研究扩大了对控制脊柱运动神经发育的分子机制的理解.