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Updated: Feb 28, 2026

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
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Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Published on: March 13, 2018

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低背景癌症成像使用生物直角光探测器和工程记者酶携带准组件的工程记者酶

Ziyi Wang1, Ryosuke Kojima1, Rikuki Kiji2

  • 1Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|February 27, 2026
PubMed
概括

这项研究开发了一种新的生物直角光探针 (HMRef-β-d-Fucose) 和一种工程酶 (Td2F2),用于精确的癌症手术. 这种组合最大限度地减少了背景信号,使得癌细胞在体内能够更清晰地可视化.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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