对于焦虑障碍的集群随机对照试验中的类内相关性:来自元分析的证据
Binukumar Bhaskarapillai1, Palash Kumar Malo2, M Thomas Kishore3
1Department of Biostatistics, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.
Indian journal of psychiatry
|March 9, 2026
概括
对焦虑症的集群随机试验 (CRT) 的综合类内相关系数 (ICC) 为0.05. 这一元分析强调了对报告标准的遵守程度较低,为CRT中未来的样本大小计算提供了参考.
科学领域:
- 临床心理学 临床心理学
- 生物统计学 生物统计学
- 精神病学研究 精神病学研究
背景情况:
- 集群随机试验 (CRT) 将干预污染最小化,但可以降低统计效率.
- 符合报告试验综合标准 (CONSORT) 的指导方针,用于报告CRT中的类内相关系数 (ICC).
研究的目的:
- 估计聚类随机试验 (CRT) 的聚合类内相关系数 (ICC),以焦虑症为重点.
- 为了在这个领域的未来CRT中提供样本大小计算的基准.
主要方法:
- 一个系统的文献搜索确定了23项研究进行元分析.
- 使用DerSimonian和Laird的逆方差方法来计算汇总的ICC估计.
- 使用漏斗图和埃格尔回归测试来评估出版偏差.
主要成果:
- 对焦虑障碍的CRT的汇总ICC为0.05 (95%CI:0.04-0.06),观察到相当大的异质性.
- 在设计阶段和干预后报告的ICC之间没有发现显著差异.
- 道图形不对称表明了潜在的出版偏差,尽管埃格尔的测试没有显示小研究效应 (P = 0.913).
结论:
- 对于焦虑障碍的CRT中ICC报告的CONSORT建议的遵守率约为三分之二.
- 计算的聚合ICC可以作为一个有价值的参考,用于确定未来的焦虑障碍CRT中适当的样本大小.
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