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Updated: Mar 11, 2026

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使用参考基因组和 de novo 组件进行 Hi-C 支架的基准测试

Aakash Sur1, William Stafford Noble2,3, Peter J Myler4,5,6

  • 1Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, USA. asur@uw.edu.

Genome biology
|March 10, 2026
PubMed
概括

基准测试染色体构成捕获 (Hi-C) 支架揭示了性能变化. HiRise和Lachesis在各种基因组组装条件中展示了卓越的准确性,为高质量的参考基因组构建提供了可靠的解决方案.

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Genome Annotation and Assembly03:36

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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