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在缺乏Dvl1的小鼠中,社会互动和感觉运动门的异常
N Lijam1, R Paylor, M P McDonald
1Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Cell
|September 23, 1997
概括
缺乏Dvl1的小鼠表现出显著的社会行为缺陷和异常的感觉运动门,这表明该基因在与精神疾病相关的复杂行为中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发展生物学 发展生物学
背景情况:
- 分解 (Dvl) 蛋白在Wnt信号通路中至关重要.
- Dvl1是Drosophila Dishevelled基因的三个哺乳动物同类之一.
- Dvl1在哺乳动物复杂行为中的确切作用在很大程度上仍未被探索.
研究的目的:
- 为了研究完全缺乏Dvl1.1的小鼠的行为表型.
- 探索Dvl1在社会互动和感官运动门的潜在参与.
主要方法:
- 用基因向来制造Dvl1缺乏的小鼠.
- 行为评估包括社交互动测试,筑巢测试和感官运动门测量.
主要成果:
- 缺乏Dvl1的小鼠是可行的,肥沃的,结构正常的.
- 观察到社会行为的显著缺陷,包括改变了胡须修剪,损害了筑巢,减少了拥挤和下属反应.
- 显而易见的是异常的感觉运动门,在脉冲前抑制声学和触觉惊的缺陷.
结论:
- 在小鼠中,Dvl1在调节复杂的社会行为和感觉运动关门方面发挥着至关重要的作用.
- 缺乏Dvl1的小鼠代表了研究人类精神疾病方面的有价值模型.
- 这些发现表明Dvl1与复杂行为背后的遗传机制有关,并表明社会和感觉运动功能的共享途径.
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