Related Experiment Video

Updated: Aug 9, 2026

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors
19:02

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors

Published on: March 22, 2011

Targeted adenoviral vectors for cancer gene therapy

G Bilbao1, J Gómez-Navarro, D T Curiel

  • 1Gene Therapy Program, University of Alabama at Birmingham, Alabama 35294, USA.

Advances in Experimental Medicine and Biology
|February 23, 1999
PubMed

Insights

Researchers are improving adenoviral vectors for targeted cancer gene therapy. Advances aim to specifically deliver therapeutic genes to tumor cells, overcoming current limitations for effective clinical application.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Therapy

Background:

  • Cancer research increasingly focuses on molecular targets for therapeutic intervention.
  • Viral and nonviral vectors are utilized for gene delivery into malignant and non-malignant cells.
  • Recombinant adenoviruses show efficiency in in vivo gene transfer and have entered clinical trials.

Purpose of the Study:

  • To review advances in adenoviral vector technology for cancer gene therapy.
  • To address the challenge of specifically delivering therapeutic genes to tumor cells.
  • To discuss the development of "targetable-injectable" vectors for clinical translation.

Main Methods:

  • Review of current literature on adenoviral vector development for cancer.
  • Analysis of strategies to enhance tumor cell specificity.
  • Evaluation of progress towards clinical application of gene therapy vectors.

Main Results:

  • Adenoviral vectors are efficient for in vivo gene transfer.
  • Significant progress has been made in developing targeted adenoviral vectors.
  • Pre-clinical studies show promising results for improved cancer gene therapy.

Conclusions:

  • Targeted adenoviral vectors are crucial for effective cancer gene therapy.
  • Overcoming vector-related delivery obstacles is key for clinical success.
  • Advancements in vector technology are expected to accelerate clinical translation of promising pre-clinical findings.

More Related Videos

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors14:55

Production and Purification of Non Replicative Canine Adenovirus Type 2 Derived Vectors

Published on: December 3, 2013

A Validatable Droplet Digital Polymerase Chain Reaction Assay for the Detection of Adeno-Associated Viral Vectors in Bioshedding Studies of Tears07:43

A Validatable Droplet Digital Polymerase Chain Reaction Assay for the Detection of Adeno-Associated Viral Vectors in Bioshedding Studies of Tears

Published on: July 14, 2023

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...