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[Slowly progressive aphemia--a case report].

T Iwasaki1, Y Saitou, Y Wada

  • 1Department of Neurology, Tokyo Medical and Dental University.

Rinsho Shinkeigaku = Clinical Neurology
|March 17, 1999
PubMed
Summary
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This study details a 69-year-old woman with progressive speech difficulty, diagnosed as aphemia. Brain imaging revealed atrophy and hypometabolism in key speech production areas.

Area of Science:

  • Neurology
  • Neuroimaging
  • Speech Pathology

Background:

  • Aphemia, a motor speech disorder, affects speech production.
  • Progressive speech difficulty can indicate underlying neurological conditions.

Observation:

  • A 69-year-old woman presented with an 8-year history of slowly progressive, non-fluent speech.
  • She exhibited severe buccofacial apraxia but retained auditory and visual comprehension.
  • No significant intellectual decline or swallowing difficulties were noted.

Findings:

  • Three-dimensional MRI showed severe atrophy in the left inferior frontal gyrus and left pre-central gyrus.
  • FDG-PET revealed focal hypometabolism in the same brain regions.
  • These neuroimaging findings correlated with the patient's speech production deficits.

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Implications:

  • This case highlights the link between specific left frontal lobe structural and metabolic changes and aphemia.
  • Neuroimaging is crucial for diagnosing and understanding the pathophysiology of motor speech disorders.
  • Understanding these lesions can inform future therapeutic strategies for speech production difficulties.