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Rapid T2* mapping using interleaved echo planar imaging.

A M Howseman1, D L Thomas, G S Pell

  • 1Biophysics Unit, Institute of Child Health, University College London, United Kingdom.

Magnetic Resonance in Medicine
|March 18, 1999
PubMed
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This study introduces a rapid interleaved echoplanar imaging (EPI) sequence for T2* mapping. This method accurately quanties blood oxygenation changes, crucial for brain imaging and monitoring oxygenation levels.

Area of Science:

  • Biomedical Engineering
  • Neuroimaging
  • Magnetic Resonance Imaging

Background:

  • T2*-weighted magnetic resonance imaging (MRI) is vital for studying brain blood oxygenation.
  • Current methods for measuring T2* are often slow, limiting their use in dynamic monitoring.
  • Accurate quantification of T2* is needed to understand the coupling of cerebral blood flow and metabolism.

Purpose of the Study:

  • To develop and validate a rapid interleaved echoplanar imaging (EPI) sequence for T2* mapping.
  • To enable fast and accurate quantification of blood oxygenation changes.
  • To improve temporal resolution in monitoring oxygenation dynamics.

Main Methods:

  • An interleaved echoplanar imaging (EPI) sequence was developed for rapid T2* map generation.

Related Experiment Videos

  • The sequence was validated using a doped water phantom, comparing results with conventional gradient-echo methods.
  • In vivo data were acquired from the rat brain at 2.35 T.

    • Main Results:

    • The interleaved EPI sequence generates T2* maps in seconds with reduced geometric distortion.
    • Accurate T2* values were obtained, comparable to slower gradient-echo techniques.
    • High temporal resolution data from rat brains showed T2* reduction during anoxic challenges, correlating with deoxyhemoglobin levels.

    Conclusions:

    • The presented interleaved EPI sequence offers a fast and accurate method for T2* quantification.
    • This technique is valuable for monitoring blood oxygenation changes in dynamic physiological states.
    • The method holds promise for improved functional brain imaging and physiological monitoring.