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Regulation of bile acid biosynthesis
Z R Vlahcevic1, W M Pandak, R T Stravitz
1Division of Gastroenterology, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
Gastroenterology Clinics of North America
|April 13, 1999
Abstract:
This article provides a review of the pathways through which cholesterol is degraded to bile acids. Regulation of key enzymes in the bile acid biosynthestic pathways is discussed. The important role of these pathways in the maintenance of cholesterol homeostasis and the possible therapeutic implications for the treatment of hypercholesterolemia are emphasized.