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Regeneration of 4-thio-2'-deoxyuridine residues in DNA

R S Coleman¹, R M Pires

¹Department of Chemistry, The Ohio State University, Columbus 43210-1185, USA.

Bioorganic & Medicinal Chemistry Letters

|May 7, 1999

Abstract:

We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated 4-thio-2'-deoxyuridine residues by treatment with NaSH within oligodeoxynucleotides.

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