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[Serum thyroglobulin compared with ultrasonically detected recurrent goiter].
M L Hartoft-Nielsen1, J Date, U F Feldt-Rasmussen
1H:S Rigshospitalet, endokrinologisk afdeling P.
Ugeskrift for Laeger
|May 11, 1999
Summary
Serum thyroglobulin (Tg) levels can predict non-toxic goitre relapse after surgery. Elevated Tg post-resection indicates thyroid remnant growth, aiding in early detection of recurrence.
Area of Science:
- Endocrinology
- Surgical Oncology
- Thyroidology
Background:
- Non-toxic goitre resection is a common surgical procedure.
- Monitoring for recurrence after surgery is crucial for patient management.
Purpose of the Study:
- To correlate changes in serum thyroglobulin (Tg) levels with relapse after non-toxic goitre resection.
- To assess the utility of repeated serum Tg measurements in detecting thyroid remnant growth.
Main Methods:
- A longitudinal study of 39 patients over 13 years following goitre resection.
- Serum Tg levels were measured preoperatively and at various time points postoperatively.
- Thyroid volume was assessed using ultrasonography 13 years after surgery.
Main Results:
- Preoperative serum Tg was elevated in all patients.
- Mean serum Tg declined postoperatively, then increased over time, reaching 90 micrograms/L at 10 years.
- Patients with enlarged thyroid remnants (> or = 28 ml) at 13 years showed a significantly higher delta Tg (133 micrograms/L) compared to those without relapse (26 micrograms/L).
Conclusions:
- Repeated serum Tg determinations can serve as a biochemical marker for increased growth of thyroid remnants post-goitre resection.
- Monitoring serum Tg levels may aid in the early detection of goitre recurrence.