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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
[Acute transverse myelitis in systemic lupus erythematosus]
F J Romero Ganuza1, F Sebastián de la Cruz, F La Banda Brusi
1Servicio de Medicina Interna, Hospital Nacional de Parapléjicos, Complejo Hospitalario de Toledo.
Revista Clinica Espanola
|June 12, 1999
Summary
Systemic lupus erythematosus can cause acute transverse myelitis, a rare neurological complication. Early inclusion of lupus in differential diagnosis and prompt treatment with steroids and immunosuppressants improve outcomes for this myelitis.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Acute transverse myelitis is an uncommon neurological complication of systemic lupus erythematosus (SLE).
- Diagnosis can be challenging due to variable clinical presentations.
- Recent advancements in neuroimaging have aided in understanding myelitis.
Observation:
- This study reports four cases of lupic myelitis diagnosed at a single institution.
- A review of literature from the past decade, coinciding with widespread NMR availability, was conducted.
- Clinical presentations of lupic myelitis were highly variable.
Findings:
- Systemic lupus erythematosus should be considered in the differential diagnosis of acute myelitis.
- Biochemical markers of lupus activity have limited diagnostic value for myelitis.
- Nuclear Magnetic Resonance (NMR) is not conclusive for determining the etiology of myelitis.
Implications:
- Prompt diagnosis and inclusion of lupus in the differential are crucial for acute myelitis.
- Therapeutic strategies involving pulsed steroids and immunosuppressants have improved prognosis.
- Further research is needed to refine diagnostic and prognostic tools for lupic myelitis.
