Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perfusion imaging using FAIR with a short predelay.

J Zhou1, P C van Zijl

  • 1Department of Radiology, Johns Hopkins University Medical School, Baltimore, Maryland 21205-2195, USA.

Magnetic Resonance in Medicine
|June 17, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer.

Oncogene·1999
Same author

Concept design of computer-aided study on traditional Chinese drugs.

Journal of chemical information and computer sciences·1999
Same author

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes.

Nature genetics·1999
Same author

delta-catenin, an adhesive junction-associated protein which promotes cell scattering.

The Journal of cell biology·1999
Same author

Numeric modeling of the cardiovascular system with a left ventricular assist device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·1999
Same author

Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression.

Gene·1999
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
See all related articles

Flow-sensitive alternating inversion recovery (FAIR) signal intensity differences are reliable for flow quantification, unaffected by measurement timing. However, T1 difference methods show timing-dependent flow quantification due to relaxation behaviors.

Area of Science:

  • Magnetic Resonance Imaging
  • Biomedical Engineering
  • Physiology

Background:

  • Accurate quantification of physiological blood flow is crucial in various medical applications.
  • Flow-sensitive alternating inversion recovery (FAIR) and T1 difference methods are used for blood flow quantification.
  • Understanding the influence of acquisition parameters on these methods is essential for reliable results.

Purpose of the Study:

  • To theoretically and experimentally investigate the impact of predelay timing on flow quantification using FAIR and T1 difference methods.
  • To develop new equations accounting for T1 differences between tissue and arterial blood.
  • To validate theoretical predictions with experimental data.

Main Methods:

  • Theoretical analysis of signal intensity differences and T1 differences under varying predelay conditions.

Related Experiment Videos

  • Development of new equations incorporating T1 and T1a (arterial blood relaxation time).
  • Experimental validation using the FAIR excluding radiation damping (FAIRER) pulse sequence on cat brains at different predelays (0.8, 2, and 5 sec).

    • Main Results:

    • Theoretical prediction: FAIR signal intensity difference is independent of predelay when complete labeling is assumed.
    • Theoretical prediction: T1 difference quantification is significantly affected by predelay due to biexponential to monoexponential fitting.
    • Experimental results confirmed theoretical predictions for both FAIR and T1 difference methods.

    Conclusions:

    • FAIR signal intensity difference offers a robust method for flow quantification, insensitive to predelay variations.
    • T1 difference method is sensitive to predelay, requiring careful consideration of acquisition timing.
    • The developed equations accurately model the influence of relaxation times on flow quantification accuracy.