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Published on: August 17, 2018
Brain computed tomography in geriatric manic disorder
R C Young1, D E Nambudiri, H Jain
1Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA.
Background:
Excess brain changes in geriatric manic patients have been hypothesized. Few neuroimaging studies are available.
Methods:
Brain computed tomography scans in geriatric patients with manic disorder (n = 30) were compared to those in same-age control subjects (n = 18). Ratings of cortical sulcal widening (CSW), lateral ventricle-brain ratio (VBR), and related linear measures were determined.
Results:
Patients had greater CSW scores (Exact p = .002) and VBR (t = 2.51, df = 46, p < .02) compared to control subjects. CSW was positively associated with age at illness onset (rs = .46, p < .01) and age at first manic episode (rs = .53, p < .005). VBR was poorly correlated with CSW and was not associated with these indices of illness course.
Conclusions:
These findings support the need for further investigation of relationships between brain structure and clinical features in geriatric mania.
