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[Ethanol modifies the ion selectivity of sodium channels in the rat sensory neurons]
B V Krylov1, Iu Iu Vilin, I E Katina
1I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.
Abstract:
Ethanol was shown to decrease the reversal potential of tetrodotoxin-resistant (TTXr) and TTX-sensitive channels in short-term culture of the dorsal root ganglion cells. The ethanol led to alterations in ionic selectivity of the TTXr channels (its shifting from the X-th Eisenmann selectivity sequence to the XI-th one). The data obtained suggest that the findings were due to selectivity filter modification because of disturbed hydrogen bounds in the channel macromolecule.