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Related Experiment Videos

Transmural pressure inhibits prorenin processing in juxtaglomerular cell.

A Ichihara1, H Suzuki, Y Miyashita

  • 1Department of Internal Medicine, Keio University School of Medicine, Tokyo 160, Japan.

The American Journal of Physiology
|July 17, 1999
PubMed
Summary

Transmural pressure (TP) regulates renin secretion by juxtaglomerular (JG) cells. Elevated TP decreases renin secretion and active renin content via calcium influx and intracellular calcium stores, affecting prorenin processing.

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Area of Science:

  • Nephrology
  • Cell Physiology
  • Endocrinology

Background:

  • Renin secretion is influenced by shear stress, stretch, and transmural pressure (TP).
  • Understanding TP's role in renin control is crucial for managing blood pressure.

Purpose of the Study:

  • To isolate and define the mechanism of TP control on renin secretion.
  • To investigate TP's effect on juxtaglomerular (JG) cells with minimal confounding factors.

Main Methods:

  • Rat JG cells were subjected to controlled TP loading.
  • Renin secretion rate (RSR) and active renin content (ARC) were measured.
  • Effects of calcium manipulation (Ca(2+)-free medium, verapamil, thapsigargin, caffeine) were assessed.

Main Results:

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  • Increased TP significantly reduced RSR and ARC in JG cells.
  • TP-induced decreases in RSR were dependent on extracellular calcium influx.
  • TP-induced decreases in ARC were dependent on intracellular calcium stores.

Conclusions:

  • TP inhibits renin secretion through both calcium influx and intracellular calcium store-dependent mechanisms.
  • TP affects prorenin processing, leading to reduced active renin secretion by JG cells.