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Syntheses and Potato Tuber-inducing Activity of Coronafacic Acid Analogues
H Toshima1, S Nara1, A Ichihara1
1a Department of Bioscience and Chemistry, Hokkaido University.
Abstract:
Coronafacic acid (1) is an acid component of coronatine, and has been isolated from several pathovars of Pseudomonas syringae. Syntheses of C6-non- and C6-alkyl-substituted analogues of 1 were accomplished via intramolecular 1,6-conjugate addition as the key step. Among them, 1 and four C6-alkyl-substituted analogues exhibited potato tuber-inducing activity, but the C6-non-substituted analogue did not. It was revealed that a certain length of the C6-alkyl group was necessary to exhibit activity.
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