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[20 years in vitro fertilization: what follows?]
1Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin, Universitäts-Frauenklinik, Basel.
Therapeutische Umschau. Revue Therapeutique
|July 20, 1999
Summary
In vitro fertilization (IVF) has advanced significantly, improving pregnancy rates. New techniques like assisted hatching and medications offer further potential, alongside strategies for oocyte cryopreservation for fertility preservation.
Area of Science:
- Reproductive Endocrinology
- Assisted Reproductive Technologies
Context:
- In vitro fertilization (IVF) has seen global expansion over the past two decades.
- Current IVF protocols achieve over 30% pregnancy rates in many centers.
- Multiple pregnancies remain a significant complication of IVF.
Purpose:
- To explore advancements in IVF protocols for improved efficacy and safety.
- To investigate novel medications and techniques for personalized infertility treatment.
- To address the challenge of multiple pregnancies and explore fertility preservation options.
Summary:
- Optimized IVF protocols and emerging technologies like assisted hatching are enhancing success rates.
- New medications, including recombinant FSH and GnRH-antagonists, allow for tailored treatment, potentially reducing risks like ovarian hyperstimulation syndrome.
- In-vitro maturation of oocytes and cryopreservation offer alternative strategies, particularly for fertility preservation in specific patient groups.
Impact:
- Further improvements in IVF pregnancy rates are anticipated with assisted hatching and new pharmaceutical agents.
- Personalized treatment protocols using novel medications can mitigate risks and improve outcomes.
- Oocyte cryopreservation and in-vitro maturation provide valuable options for fertility preservation and may offer alternatives for specific infertility cases.