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[Cerebrospinal fluid analysis in Kirisawa-Urayama type uveitis]
1Department of Ophthalmology, Niigata University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi
|July 20, 1999
Summary
Kirisawa-Urayama type uveitis often involves the optic nerve and shows intrathecal antibody production against causative viruses. However, this study found no evidence of viral encephalitis in patients with this condition.
Area of Science:
- Ophthalmology
- Neurology
- Infectious Diseases
Context:
- Kirisawa-Urayama type uveitis is an inflammatory eye condition.
- Viral encephalitis is a serious neurological disorder.
Purpose:
- To determine if viral encephalitis occurs in patients with Kirisawa-Urayama type uveitis.
- To analyze cerebrospinal fluid (CSF) for signs of viral infection.
Summary:
- CSF analysis from nine patients with Kirisawa-Urayama type uveitis revealed mild pleocytosis in seven cases.
- Intrathecal antibody production against herpes simplex virus or varicella-zoster virus was detected in six of seven patients.
- Herpesvirus DNA was not found in the CSF of any patient via polymerase chain reaction (PCR) assay.
Impact:
- Suggests Kirisawa-Urayama type uveitis is associated with optic nerve involvement and intrathecal antibody production.
- Indicates that viral encephalitis is not a common complication of Kirisawa-Urayama type uveitis.