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New screening methods for donor eye-bank eyes.
1Lions Eye Bank of Oregon Research Laboratory, Portland, USA. materry@teleport.com
Cornea
|July 28, 1999
Summary
Orbscan pachymetry mapping can screen donor corneas for abnormalities. This technique identifies abnormal corneal thickness related to surgery or diseases like keratoconus, improving donor tissue selection for transplantation.
Area of Science:
- Ophthalmology
- Corneal Transplantation
- Ophthalmic Imaging
Background:
- Current donor eye screening for corneal transplantation may not detect all topographic abnormalities.
- Effective screening is crucial to ensure the success of corneal grafts.
Purpose of the Study:
- To evaluate the utility of Orbscan corneal-thickness maps for screening donor corneas.
- To determine if pachymetry mapping can identify corneas with abnormal topography unsuitable for transplantation.
Main Methods:
- Forty donor eyes were analyzed using Orbscan to generate corneal-thickness maps.
- Central pachymetry was compared to the thinnest midperipheral thickness.
- Eyes with a history of photorefractive keratectomy (PRK) and keratoconus were compared to normal controls.
Main Results:
- Normal donor eyes showed minimal central to midperipheral thickness variation (0.040 ± 0.026 mm).
- Eyes with PRK exhibited significant central thinning (0.154 mm and 0.106 mm differences).
- Keratoconus eyes displayed thinner midperipheral corneas, indicating ectasia.
Conclusions:
- Orbscan pachymetry mapping effectively differentiates normal corneas from those with altered thickness profiles due to surgery or disease.
- This technique aids in screening donor tissue for corneal transplantation by identifying topographical irregularities.