Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrostatic charging during a melt agglomeration process.

H Eliasen1, H G Kristensen, T Schaefer

  • 1The Royal Danish School of Pharmacy, Department of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark.

International Journal of Pharmaceutics
|July 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Competition kinetics of OH radical reactions with oxygenated organic compounds in aqueous solution: rate constants and internal optical absorption effects.

Physical chemistry chemical physics : PCCP·2018
Same author

Ecotropic viral integration site 1, a novel oncogene in prostate cancer.

Oncogene·2016
Same author

Sublimation in bright spots on (1) Ceres.

Nature·2015
Same author

Multiphase chemistry of glyoxal: revised kinetics of the alkyl radical reaction with molecular oxygen and the reaction of glyoxal with OH, NO3, and SO4- in aqueous solution.

Environmental science & technology·2014
Same author

Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study.

The British journal of dermatology·2013
Same author

[The fate of 20 sea breams. Mycobacterium marinum infection].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2012
Same journal

Design and evaluation of a pump-free ultrasonic atomization-driven hollow microneedle array for transdermal drug delivery.

International journal of pharmaceutics·2026
Same journal

Predicting milling performance of pharmaceutical crystals from elastic modulus.

International journal of pharmaceutics·2026
Same journal

Lipid digestion- driven drug fate as a key determinant of SNEDDS performance: Mechanistic basis of absorption and in vitro- in vivo disconnect.

International journal of pharmaceutics·2026
Same journal

Redox-responsive nanomedicine beyond glutathione: harnessing reactive oxygen species and emerging endogenous triggers for precision drug delivery.

International journal of pharmaceutics·2026
Same journal

Preventing tablet defects through vacuum-assisted deaeration of a powder bed.

International journal of pharmaceutics·2026
Same journal

Approaches for enhancing bioavailability of macromolecular drugs.

International journal of pharmaceutics·2026
See all related articles

Melt agglomeration of lactose monohydrate was studied using different meltable binders. Stearic acid generated significant electrostatic charges, while polyethylene glycol (PEG) 3000 produced fewer, impacting material adhesion.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Melt agglomeration is a key process in pharmaceutical manufacturing for particle design.
  • Controlling electrostatic charging during high shear mixing is crucial for process efficiency and safety.

Purpose of the Study:

  • To investigate the effect of various meltable binders on electrostatic charging during lactose monohydrate melt agglomeration.
  • To correlate binder properties and processing conditions with charge levels and material adhesion.

Main Methods:

  • Lactose monohydrate was melt agglomerated in a high shear mixer using stearic acid, polyethylene glycol (PEG) 3000, and a stearic acid/glycerol monostearate mixture.
  • Electrostatic charging was monitored via probe voltage at 35% and 75% relative humidity.
  • Binder resistivity was measured and correlated with charge levels.

Related Experiment Videos

Main Results:

  • Stearic acid generated high electrostatic charges; PEG 3000 generated significantly lower charges.
  • Adding glycerol monostearate to stearic acid reduced electrostatic charges.
  • A positive correlation was observed between binder resistivity and electrostatic charge levels.
  • Higher charges were measured at lower relative humidity when using stearic acid and the binder mixture.
  • Material adhesion to the mixer bowl was dependent on the level of electrostatic charges.

Conclusions:

  • Binder selection significantly influences electrostatic charging during melt agglomeration.
  • Binder resistivity and relative humidity are critical factors affecting charge generation.
  • Managing electrostatic charges is essential for controlling material adhesion and optimizing the melt agglomeration process.