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Synthesis of cis-disubstituted cyclobutenyl nucleoside analogues
1Laboratoire de Synthèse Organique, ESA 6011, Faculté des Sciences, Université du Maine, Le Mans, France.
Nucleosides & Nucleotides
|August 5, 1999
Abstract:
cis-Disubstituted cyclobutene nucleosides analogues were prepared by a linear synthesis starting from cis-cyclobutene dicarboxylic anhydride. This strategy involved mild reaction conditions with intent to restrict the thermal electrocyclic ring opening into (Z,E)-dienes.