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09:21

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[Acute hemolytic anemia in Clostridium perfringens infection]

E H Duun1, I M Schiødt, O J Bergmann

  • 1Medicinsk haematologisk afdeling L, Amtssygehuset i Herlev.

Ugeskrift for Laeger
|August 6, 1999
PubMed

Insights

Clostridium perfringens can cause rare hemolytic anemia in cancer patients. This case highlights the first survival of multiple myeloma with C. perfringens septicemia, acute hemolysis, and anuria, suggesting penicillin treatment.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • Clostridium perfringens-induced hemolytic anemia is a rare complication in patients with neoplastic diseases.
  • Malignancy, particularly multiple myeloma, presents unique challenges in managing severe infections.

Observation:

  • A patient with multiple myeloma developed Clostridium perfringens septicemia.
  • The patient experienced acute hemolytic anemia and acute anuria concurrently with the septicemia.

Findings:

  • This case represents the first documented survival of a patient with multiple myeloma experiencing C. perfringens septicemia complicated by acute hemolysis and anuria.
  • Prompt administration of penicillin was crucial in the patient's recovery.

Implications:

  • Penicillin should be considered for febrile patients with acute hemolytic anemia when no other cause is evident.
  • Early recognition and treatment of C. perfringens infections in immunocompromised patients are critical for survival.

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