Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conserved genetic programs in insect and mammalian brain development.

F Hirth1, H Reichert

  • 1Institute of Zoology, University of Basel, Rheinsprung 9, CH-4051 Basel, Switzerland.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|August 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium.

Toxicological sciences : an official journal of the Society of Toxicology·2025
Same author

Arteriovenous Fistulae for Haemodialysis: A Systematic Review and Meta-analysis of Efficacy and Safety Outcomes.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2017
Same author

Segmental differentiation processes in embryonic muscle development of the grasshopper.

Roux's archives of developmental biology : the official organ of the EDBO·2017
Same author

Early development of the Drosophila mushroom bodies, brain centres for associative learning and memory.

Development genes and evolution·2016
Same author

Exploiting coherence for real-time studies by single-bunch imaging.

Journal of synchrotron radiation·2014
Same author

Memorandum on the use of information technology to improve medication safety.

Methods of information in medicine·2014
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Developmental genes like orthodenticle (otd/Otx) and Hox are conserved across animals, controlling body plan and brain development. Their conserved function in insects and mammals highlights evolutionary links in pattern formation.

Area of Science:

  • Developmental Biology
  • Evolutionary Genetics
  • Neuroscience

Background:

  • Developmental regulatory genes are crucial for establishing the embryonic body plan.
  • The orthodenticle (otd/Otx) and Hox gene families play key roles in anteroposterior axis specification.
  • Conserved genetic mechanisms are increasingly recognized across diverse animal species.

Purpose of the Study:

  • To investigate the conserved roles of otd/Otx and Hox genes in embryonic patterning.
  • To examine the involvement of these gene families in both insect and mammalian brain development.
  • To explore the evolutionary conservation of genetic mechanisms underlying pattern formation.

Main Methods:

  • Comparative genomics and gene expression analysis in Drosophila and mouse models.

Related Experiment Videos

  • Functional studies involving cross-phylum rescue experiments.
  • Analysis of otd/Otx gene family interactions and functional redundancy.

    • Main Results:

    • otd/Otx genes are implicated in rostral brain development, while Hox genes are involved in caudal brain development.
    • Cross-phylum rescue experiments demonstrate functional interchangeability within the otd/Otx gene family.
    • Evidence suggests conserved genetic pathways for brain pattern formation in insects and mammals.

    Conclusions:

    • The otd/Otx and Hox gene families are fundamental to conserved developmental processes across the animal kingdom.
    • Genetic mechanisms controlling brain development show significant evolutionary conservation between insects and mammals.
    • Functional conservation of otd/Otx genes underscores deep evolutionary relationships in developmental regulation.