Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac diffusion tensor MRI in vivo without strain correction.

W Y Tseng1, T G Reese, R M Weisskoff

  • 1Department of Radiology, NMR Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.

Magnetic Resonance in Medicine
|August 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A haplotype of the dopamine transporter gene modulates regional homogeneity, gray matter volume, and visual memory in children with attention-deficit/hyperactivity disorder.

Psychological medicine·2018
Same author

Differential effects of methylphenidate and atomoxetine on intrinsic brain activity in children with attention deficit hyperactivity disorder.

Psychological medicine·2016
Same author

Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR.

Physics in medicine and biology·2015
Same author

Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study.

Physics in medicine and biology·2013
Same author

Disturbed microstructural integrity of the frontostriatal fiber pathways and executive dysfunction in children with attention deficit hyperactivity disorder.

Psychological medicine·2012
Same author

Improving diffusion MRI using simultaneous multi-slice echo planar imaging.

NeuroImage·2012
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
See all related articles

This study introduces a novel cardiac diffusion MRI method using "sweet spots" during the cardiac cycle to eliminate strain correction. This technique accurately captures myocardial fiber orientation, even with cardiac motion.

Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Magnetic Resonance Imaging

Background:

  • Cardiac diffusion MRI is challenged by myocardial strain during the cardiac cycle.
  • Accurate diffusion data acquisition requires accounting for these dynamic cardiac strains.

Purpose of the Study:

  • To present a method for acquiring accurate cardiac diffusion MRI data without the need for strain correction.
  • To identify specific time points within the cardiac cycle, termed "sweet spots," where strain effects are minimized.

Main Methods:

  • Diffusion encoding was performed at identified "sweet spots" during the cardiac cycle.
  • The method was validated using cyclically deformed gel phantoms and diffusion MRI in five healthy subjects.
  • Strain-rate movies were acquired to predict and verify the timing of "sweet spots."

Related Experiment Videos

Main Results:

  • In phantoms, predicted "sweet spots" correlated with accurate diffusion measurements.
  • In human subjects, a high correlation (r = 0.99) was observed between predicted "sweet spots" and diffusion trace locations.
  • Cardiac diffusion MRI successfully revealed myocardial fiber orientation patterns comparable to stationary specimens.

Conclusions:

  • The "sweet spot" method enables accurate cardiac diffusion MRI by minimizing strain effects.
  • This approach provides reliable myocardial fiber orientation mapping in vivo.
  • The findings offer a significant advancement for cardiac diffusion MRI applications.