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Selection of candidate genes for population studies
1Pharmacogenetic Section, Genetic Epidemiology Branch, National Cancer Institute, Rockville, MD 20892, USA.
IARC Scientific Publications
|September 24, 1999
Summary
Common cancers involve multiple genetic susceptibility loci, not just high-penetrance genes. Research is expanding to include genes in DNA repair and cell cycle control, focusing on candidate gene selection.
Area of Science:
- Human genetics
- Cancer research
- Molecular biology
Background:
- Genetic susceptibility to cancer varies; rare tumors are linked to high-penetrance genes, while common cancers involve multiple susceptibility loci.
- Previous research focused on genes involved in carcinogen metabolism (activation and detoxification).
Purpose of the Study:
- To explore methodological issues in studying common genetic susceptibility in cancer.
- To emphasize the importance of selecting appropriate candidate genes for research.
Main Methods:
- Review of existing literature on genetic susceptibility in common cancers.
- Discussion of candidate gene selection strategies for complex genetic studies.
Main Results:
- Current research extends beyond carcinogen metabolism to genes involved in DNA repair, cell cycle control, and nutrient metabolism.
- The selection of candidate genes is a critical methodological consideration.
Conclusions:
- Understanding the genetic basis of common cancers requires investigating a diverse range of genes and their mechanisms.
- Methodological rigor, particularly in candidate gene selection, is crucial for advancing research in this area.