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Activity of vinorelbine on B-chronic lymphocytic leukemia cells in vitro
P A Bernabei1, I Landini, B Bartolozzi
1Università degli Studi-Azienda Ospedaliera di Careggi, Firenze, Italy.
Advances in Experimental Medicine and Biology
|September 29, 1999
Abstract:
Vinorelbine (VNR) is a new semi-synthetic Vinca rosea alkaloid that has been employed both in combination and as a single agent, showing a significant antitumour activity. Since little is known about VNR in human leukemia, we studied the in vitro cytotoxic effect of VNR on peripheral blood lymphocytes from 18 patients affected by B-chronic lymphocytic leukemia (CLL), employing the INT assay. VNR inhibited fresh B-CLL cells from 15/18 patients in primary cultures, the ID50 doses ranging from 4 ng/ml to 83 micrograms/ml. These data strongly suggest that VNR could be effective in the treatment of B-CLL.