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[Standardization of hazel leaf].

D Fraisse1, A Carnat, A P Carnat

  • 1Laboratoire de Pharmacognosie et Phytothérapie, Faculté de Pharmacie, Clermont-Ferrand.

Annales Pharmaceutiques Francaises
|October 16, 1999
PubMed
Summary
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This study analyzed Corylus avellana L. leaves, finding consistent total flavonoid levels but variations in myricitrin, quercitrin, and tannins between harvested and commercial batches. These findings inform potential pharmacopoeial standards.

Area of Science:

  • Phytochemistry
  • Pharmacognosy
  • Botany

Context:

  • Analysis of dried leaves from Corylus avellana L. (hazel), encompassing 9 harvested and 5 commercial batches.
  • Focus on quantifying key polyphenolic compounds within the plant material.

Purpose:

  • To determine and compare the levels of principal polyphenolic compounds in Corylus avellana L. leaves.
  • To provide data for the discussion of specifications for a French Pharmacopoeial monography.

Summary:

  • Average levels of total flavonoids were consistent (2.58%) across both harvested and commercial Corylus avellana L. leaf batches.
  • Myricitrin, quercitrin, and tannins showed variations: myricitrin (1.09% vs 1.35%), quercitrin (0.30% vs 0.40%), and tannins (5.2% vs 6.5%) respectively.
  • The quantitative data on these polyphenols are relevant for establishing quality standards.

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Impact:

  • Provides essential phytochemical data for Corylus avellana L. leaf standardization.
  • Contributes to the development of pharmacopoeial monographs for herbal medicinal products.
  • Highlights potential variability in active compounds based on origin (harvested vs. commercial).