Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anecdotal therapies.

L E Millikan1

  • 1Department of Dermatology, Tulane University Medical Center, New Orleans, Louisiana 70112, USA. millikan@tmcpop.tmc.tulane.edu

Advances in Experimental Medicine and Biology
|December 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pivotal clinical trials of adapalene in the treatment of acne.

Journal of the European Academy of Dermatology and Venereology : JEADV·2002
Same author

Androgenetic alopecia: the role of inflammation and Demodex.

International journal of dermatology·2001
Same author

Cosmetology, cosmetics, cosmeceuticals: definitions and regulations.

Clinics in dermatology·2001
Same author

Role of oral antifungal agents for the treatment of superficial fungal infections in immunocompromised patients.

Cutis·2001
Same author

Posttransplant primary cutaneous T-cell lymphoma.

Journal of the American Academy of Dermatology·2001
Same author

Adapalene: an update on newer comparative studies between the various retinoids.

International journal of dermatology·2000
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Anecdotal evidence often initiates medical discoveries, but rigorous trials are crucial for validating therapies. This approach remains vital for rare diseases and areas lacking conventional treatments.

Area of Science:

  • Dermatology
  • Pharmacology
  • Medical History

Background:

  • Many medical advancements originate from serendipitous discoveries and anecdotal reports.
  • Anecdotal indications are common for existing drugs and topical treatments in dermatology.
  • Geographic variations and unmet therapeutic needs drive the use of anecdotal therapies.

Purpose of the Study:

  • To explore the role and significance of anecdotal evidence in medical and therapeutic development.
  • To discuss the historical context and evolution of anecdotal therapies alongside regulatory frameworks.
  • To examine the balance between anecdotal approaches and rigorous scientific validation in medicine.

Main Methods:

  • Review of historical medical practices and folk medicine.

Related Experiment Videos

  • Analysis of case studies involving anecdotal therapies (e.g., Skin Cap, Trental, zinc preparations).
  • Discussion of regulatory evolution (FDA) influenced by drug safety events (e.g., thalidomide) and public health crises (e.g., AIDS).

    • Main Results:

    • Anecdotal reports have historically led to significant therapeutic discoveries.
    • Standardization and regulation (FDA) aim to ensure drug safety and efficacy, sometimes limiting anecdotal use.
    • Expedited review processes, influenced by crises like AIDS, represent a shift in regulatory balance.
    • Anecdotal therapies remain critical for orphan diseases and conditions with limited treatment options.

    Conclusions:

    • Anecdotal evidence serves as a crucial starting point for medical research and therapy development.
    • Balancing anecdotal insights with robust scientific validation and regulation is essential for safe and effective medicine.
    • The role of anecdotal therapy continues to evolve, particularly for challenging and rare diseases.