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The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology

Toni K Träger1, Fotis L Kyrilis2, Greg Kafetzopoulos2

  • 1Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology, Integrative Structural Biochemistry, Biozentrum, Halle, Germany.

Advances in Experimental Medicine and Biology
|June 23, 2026
PubMed

Keywords:
Acetyl-CoACitric acid cycleEnzyme regulationGlycolysisHistone acetylationKeto acid dehydrogenase complex familyKrebs cycleMetabolic diseasesMetabolonMitochondriaMitochondrial pyruvate carrierNuclear functionPyruvate oxidation regulationRespirasomeStructural biologyTCA cycle

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