The role of collagen in bladder filling

While this model is speculative, it is attractive in that it can account for the physiologic properties of the bladder. It also implies that connections must exist between the tension generating elements, i.e., the smooth muscle cells, and the other components of the bladder. In bladders that become noncompliant, it is likely that there is some interference with the ability of the collagen fibers to elastically and reversibly alter their tortuosity. This, predictably, would reduce total bladder capacity. Further studies will be required to establish the relationship between compliance changes and the passive mechanical elements of the bladder wall that comprise its structural protein matrix.