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Experimental murine leishmaniasis and the Th1/Th2 cell concept
M Lohoff1, A Gessner, C Bogdan
1Institut für Klinische Mikrobiologie & Immunologie, University of Erlangen, Germany.
The Tokai Journal of Experimental and Clinical Medicine
|January 6, 2000
Summary
Murine cutaneous leishmaniasis research highlights the crucial roles of T helper 1 (Th1) and T helper 2 (Th2) cells in immune responses. This study details their generation and impact on the immune system.
Area of Science:
- Immunology
- Parasitology
Background:
- The Th1/Th2 concept, initially based on cytokine profiles, defines distinct immune pathways impacting various immune cells.
- Murine experimental leishmaniasis serves as a key model for understanding Th1/Th2 responses in vivo.
Purpose of the Study:
- To summarize current knowledge on immune responses in murine cutaneous leishmaniasis.
- To elucidate the generation and characteristics of Th1 and Th2 cells in this disease model.
Main Methods:
- Review of existing literature on immune responses in murine cutaneous leishmaniasis.
- Presentation of specific data concerning IL-4 receptor allotypes, IRF-1, and iNOS.
Main Results:
- The Th1/Th2 paradigm significantly influences the immune system's response to leishmaniasis.
- Specific molecular players like IL-4 receptor allotypes, IRF-1, and iNOS are critical in modulating the immune response.
Conclusions:
- Murine cutaneous leishmaniasis provides essential insights into the in vivo relevance of the Th1/Th2 concept.
- Understanding these immune pathways is vital for developing strategies against leishmaniasis.