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Updated: Aug 13, 2026
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Re-evaluation of the natural course of bullous pemphigoid. A prospective study
K P Kyriakis1, V A Paparizos, D N Panteleos
1Department of Dermatology, West Attica General Hospital, Athens, Greece.
Background:
Few studies of prospectively collected data regarding the natural course of bullous pemphigoid have been performed.
Methods:
The following factors were combined both quantitatively and qualitatively to obtain results: gender, clinical activity based on the estimation of the body area involvement, disease duration, relapses, coexistence with other disease states, and serology Twenty-seven consecutive patients were followed up for 1 year.
Results:
Most disease activity (85.2%) is exhibited in the first year after onset. There is a lack of parameters with clear predictive significance. The extent and severity of skin involvement are equally distributed between the sexes and not affected by the disease duration. The generalized form of the disease is predominant (86.5%). The average clinical activity in relapses within the year of follow-up is 48% of the initially observed attack. The probability for recurrence is higher in seropositive patients (overall 37%). Coexistence with other disease states seems to be a random chance event.
Conclusions:
The lack of parameters with predictive importance underlines the necessity of a thorough follow-up to prevent treatment-related complications in elderly patients.
