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[A case of bladder tumor producing granulocyte colony-stimulating factor]
Hinyokika Kiyo. Acta Urologica Japonica
|February 5, 2000
Summary
This case report details a rare bladder tumor producing granulocyte colony-stimulating factor (G-CSF). Surgical removal normalized elevated white blood cell counts and G-CSF levels, highlighting a potential treatment avenue.
Area of Science:
- Oncology
- Urology
- Hematology
Background:
- Bladder tumors can rarely produce granulocyte colony-stimulating factor (G-CSF).
- This report presents a case of a 78-year-old male with macroscopic hematuria due to a bladder tumor.
Observation:
- Cystoscopy revealed a large bladder tumor; imaging showed right hydronephrosis without metastasis.
- Histology identified sarcomatoid carcinoma with transitional cell carcinoma and polymorphonuclear leukocyte infiltration.
- Immunohistochemistry confirmed high G-CSF concentration within the tumor specimen.
Findings:
- Preoperative peripheral white blood cell count (45,400/mm3) and serum G-CSF (73.4 pg/ml) were significantly elevated.
- Post-surgical normalization of these markers was observed.
- This represents the 19th reported case of G-CSF-producing bladder tumor in Japan.
Implications:
- G-CSF producing bladder tumors have a historically poor prognosis, with 14 of 19 reported cases dying within a year.
- This case suggests that surgical intervention may normalize G-CSF levels.
- Close follow-up is crucial for patients with this rare and aggressive malignancy.