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Correlation between left ventricular diastolic function and exercise testing in patients with old myocardial
D Zdrenghea1, D Predescu, S Oprea
1Department of Cardiology, Rehabilitation Hospital, Cluj-Napoca, Romania.
Summary
Left ventricular diastolic dysfunction correlates with myocardial ischemia in myocardial infarction (MI) patients, but not with their effort capacity. Diastolic function predicts ischemia severity, especially in anterior MI.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Diagnostic Imaging
Background:
- Left ventricular (LV) systolic function is not correlated with effort capacity in myocardial infarction (MI) patients.
- Emerging evidence suggests a potential link between LV diastolic function and exercise capacity in MI survivors.
Purpose of the Study:
- To investigate the relationship between LV diastolic function and exercise capacity in patients with old MI.
- To determine if LV diastolic dysfunction correlates with myocardial ischemia and effort capacity.
Main Methods:
- Twenty-five patients with old MI underwent maximal symptom-limited exercise testing (ET) and echocardiography.
- Calculated parameters included functional aerobic impairment (FAI), myocardial aerobic impairment (MAI), maximal exercise capacity (METs NYHA class), isovolumic relaxation time (IVRT), E and A wave velocities, and E/A rate.
Main Results:
- A significant negative correlation was found between MAI and E velocity (r = -0.68).
- No significant correlation was observed between MAI and A velocity or IVRT.
- LV diastolic function indices were altered in anterior MI but not inferior MI, correlating with myocardial necrosis extent.
Conclusions:
- LV diastolic function does not correlate with the effort capacity of MI patients.
- LV diastolic dysfunction is linked to myocardial ischemia, serving as a predictor of ischemia severity, particularly in anterior MI.