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[Sertoli-Leydig tumor. Clinical case]
A Huneeus1, F Alba, W Fernández
1Instituto de Investigaciones Materno Infantil, Universidad de Chile.
Revista Medica De Chile
|February 11, 2000
Summary
A rare ovarian tumor, Sertoli-Leydig, was diagnosed in a 16-year-old girl with secondary amenorrhea and hirsutism. Surgical removal of the left ovarian tumor was successful, confirming the diagnosis.
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
- Pathology
Background:
- Sertoli-Leydig cell tumors are rare ovarian neoplasms, typically presenting in young women.
- These tumors can cause significant hormonal disturbances, leading to symptoms like amenorrhea and hirsutism.
- Obesity, indicated by a high body mass index (BMI), can sometimes be associated with gynecological conditions.
Observation:
- A 16-year-old female presented with secondary amenorrhea, voice coarsening, hirsutism, and a BMI of 35 kg/m2.
- Pelvic ultrasound and CT scans revealed a dense retro-uterine mass.
- Surgical exploration identified a left ovarian tumor.
Findings:
- Pathological examination confirmed the excised ovarian tumor as a Sertoli-Leydig cell tumor.
- This diagnosis explains the patient's hormonal symptoms and virilization.
- The tumor was successfully removed surgically.
Implications:
- Early diagnosis and surgical management are crucial for favorable outcomes in Sertoli-Leydig tumors.
- This case highlights the importance of investigating hormonal abnormalities in adolescent girls.
- Further research into the hormonal milieu and potential genetic factors associated with these tumors is warranted.