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Characteristics of pharmaceutical grade phyllosilicate compacts
C Viseras1, A Yebra, A López-Galindo
1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Spain. cviseras@platon.ugr.es
Pharmaceutical Development and Technology
|February 12, 2000
Summary
This study evaluated phyllosilicates as direct-compression tablet excipients. Fibrous minerals like palygorskites and sepiolites showed lower elastic recovery and strength compared to laminar smectites, suggesting potential applications in tablet formulation.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Geology
Background:
- Direct-compression tablet manufacturing is a cost-effective pharmaceutical process.
- Excipients play a crucial role in tablet integrity and performance.
- Phyllosilicates, including smectites, palygorskites, and sepiolites, are clay minerals with potential pharmaceutical applications.
Purpose of the Study:
- To investigate the suitability of smectites, palygorskites, and sepiolites as direct-compression tablet excipients.
- To evaluate the mechanical properties, specifically elastic recovery and tensile strength, of compacts formed from these phyllosilicates.
Main Methods:
- Three groups of phyllosilicates (two smectites, three palygorskites, two sepiolites) were tested.
- Compact tablets were prepared using three different compression loads.
- Elastic recovery and tensile strength of the compacts were measured.
Main Results:
- Fibrous phyllosilicates (palygorskites, sepiolites) exhibited lower elastic recovery than laminar smectites.
- Smectite compacts maintained dimensions post-compression, while fibrous compacts showed slight dimensional increases.
- Compacts made from laminar particles generally possessed higher mechanical strength than those from fibrous particles.
Conclusions:
- Particle morphology and hydration water influence the compact properties of phyllosilicates.
- Smectite from Gádor, Spain, and sepiolite from Vicálvaro, Spain, demonstrated promising properties for direct-compression tablet excipient use.