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[Ropivacaine]
J L Aguilar1, M A Mendiola, A Pedrero
1Servicio de Anestesiología, Hospital Cruz Roja, Palma de Mallorca.
Revista Espanola De Anestesiologia Y Reanimacion
|February 12, 2000
Summary
Ropivacaine, an amide local anesthetic, offers intermediate duration and reduced motor blockade and toxicity compared to bupivacaine. It is widely used for various anesthesia and analgesia applications.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Ropivacaine is an amide-type local anesthetic.
- It is chemically related to mepivacaine and bupivacaine.
- Its duration of action is between that of mepivacaine and bupivacaine.
Purpose of the Study:
- To describe the pharmacological, pharmacokinetic, and pharmacodynamic features of ropivacaine.
- To compare ropivacaine with bupivacaine regarding motor blockade and toxicity.
Main Methods:
- Experimental and clinical evaluations of ropivacaine.
- Review of its chemical structure and relation to other local anesthetics.
Main Results:
- Ropivacaine exhibits less potent motor blockade than bupivacaine.
- Ropivacaine demonstrates reduced toxicity to the central nervous system and myocardial tissue.
- It has an intermediate duration of effect compared to mepivacaine and bupivacaine.
Conclusions:
- Ropivacaine is a valuable local anesthetic with a favorable safety profile.
- Its efficacy and safety support its use in various anesthetic and analgesic procedures.
- Available concentrations include 0.2%, 0.75%, and 1%.