Correlation of asymmetric Notch2 expression and mouse incisor rotation

Notch signaling defines an evolutionarily conserved cell communication mechanism, which enables neighboring cells to adopt different fates. Furthermore, Notch signaling may create boundaries that direct both the growth and patterning of the developing organs. Here we report on the expression of Notch receptors during the development of rodent incisors. Before the acquisition of their characteristic shape, incisors rotate antero-posteriorly and become asymmetric at their labial-lingual axis. Notch2 is expressed only in the anterior part of the developing incisors, well before their rotation, while Notch2 expression was symmetrical in the developing molars. This is the first demonstration of an asymmetric gene expression pattern during the rotation of the rodent incisors.