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Phytochemicals as modulators of cancer risk
H L Bradlow1, N T Telang, D W Sepkovic
1Strang Cancer Research Laboratory, New York, NY 10021, USA.
Abstract:
These results, describing antitumor activity of some of the phytochemicals that have been actively studied, suggest that dietary changes could play a role in decreasing the incidence of a variety of tumors. 13C and the other compounds discussed may well be only prototypes for other as yet unexplored phytochemicals present in the diet. There have been no attempts to explore the possibilities of synergistic action among the various phytochemicals, 13C, limonene, curcumin, epigallocatechin gallate, sulforaphene, or genistein. Mixtures of these compounds might well show potency at lower doses for each of the compounds and show even greater promise than that already demonstrated.
Insights
Dietary phytochemicals show antitumor activity, suggesting diet modification can reduce tumor incidence. Further research into synergistic effects of compounds like limonene and curcumin may enhance their therapeutic potential.
Area of Science:
- Nutritional Science
- Oncology
- Pharmacology
Background:
- Phytochemicals are plant-derived compounds studied for their health benefits.
- Some phytochemicals exhibit promising antitumor activity.
- Dietary patterns are increasingly recognized for their role in cancer prevention.
Purpose of the Study:
- To review the antitumor activity of well-studied phytochemicals.
- To explore the potential of dietary changes in cancer prevention.
- To highlight the need for research into phytochemical synergy.
Main Methods:
- Literature review of studies on phytochemicals and antitumor activity.
- Analysis of existing data on compounds such as 13C, limonene, curcumin, epigallocatechin gallate, sulforaphene, and genistein.
- Identification of research gaps concerning synergistic effects.
Main Results:
- Several studied phytochemicals demonstrate significant antitumor effects.
- Dietary intake of these compounds may contribute to reducing tumor incidence.
- The potential for synergistic interactions among phytochemicals remains largely unexplored.
Conclusions:
- Dietary modifications incorporating specific phytochemicals could be a strategy for cancer risk reduction.
- Further investigation into the combined effects of phytochemicals is warranted.
- Unexplored phytochemicals in the diet may also hold therapeutic promise.