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Human alpha-fetoprotein transcriptional regulatory sequences. Application to gene therapy

T Tamaoki1

  • 1Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada.

Advances in Experimental Medicine and Biology
|May 16, 2000
PubMed

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General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...