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Related Experiment Videos

Low-dose broad-band UVA in morphea using a new method for evaluation.

M El-Mofty1, H Zaher, M Bosseila

  • 1Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.

Photodermatology, Photoimmunology & Photomedicine
|May 24, 2000
PubMed
Summary

Low-dose broad-band ultraviolet A (UVA) phototherapy effectively softened localized scleroderma lesions. This safe treatment significantly reduced collagen concentration in affected skin areas, offering a promising new option.

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Area of Science:

  • Dermatology
  • Photomedicine
  • Connective Tissue Diseases

Background:

  • Localized scleroderma treatments have historically shown limited efficacy.
  • Phototherapy, including psoralen-plus-UVA (PUVA), has emerged as a potential therapeutic option.
  • Broad-band ultraviolet A (UVA) phototherapy offers a distinct approach to treating localized scleroderma.

Purpose of the Study:

  • To evaluate the therapeutic effect of low-dose broad-band UVA phototherapy on localized scleroderma.
  • To assess treatment efficacy using clinical evaluation and quantitative collagen measurement.
  • To determine the safety and effectiveness of this phototherapy modality.

Main Methods:

  • Twelve patients with localized scleroderma (morphea) received UVA irradiation (20 J/cm2, 3x/week for 20 sessions).

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  • Treated plaques were compared to untreated, covered plaques as internal controls.
  • Clinical assessment (inspection, palpation) and computerized image analysis of collagen concentration in biopsy specimens were performed.

    • Main Results:

    • All patients reported significant skin lesion softening, confirmed by palpation.
    • A statistically significant reduction in dermal collagen concentration was observed in UVA-exposed plaques (P=0.007).
    • No significant change in collagen concentration was noted in the control plaques (P=0.10).

    Conclusions:

    • Low-dose broad-band UVA phototherapy is a highly effective treatment for localized scleroderma.
    • The observed reduction in collagen concentration supports the clinical findings of lesion softening.
    • This phototherapy modality demonstrates a favorable safety and efficacy profile for localized scleroderma.