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Drug release from Carbomer 934 matrices.

L I Russo1, E S Ghaly

  • 1University of Puerto Rico, School of Pharmacy, San Juan 00936-5067.

Puerto Rico Health Sciences Journal
|July 26, 2000
PubMed
Summary

Drug release from Carbomer 934 hydrogel matrices was studied. Findings show polymer concentration, diluent type, and matrix restriction significantly influence theophylline release mechanism and rate.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Carbomer 934 hydrogels are widely used for controlled drug release.
  • Understanding drug release mechanisms is crucial for optimizing dosage forms.

Purpose of the Study:

  • To elucidate the drug release mechanism of theophylline from Carbomer 934 matrices.
  • To investigate the impact of Carbomer concentration, diluent choice, and matrix surface restriction on drug release kinetics.

Main Methods:

  • Formulations with varying Carbomer 934 levels (10-50%) and direct compressible diluents were prepared.
  • Theophylline release was assessed using USP Apparatus 1.
  • Korsmeyer-Peppas equation was applied to determine the release mechanism.

Main Results:

  • Drug release mechanisms were influenced by Carbomer level, diluent type, and matrix restriction.
  • Anomalous (non-Fickian) release was generally observed, with Super Case II in specific formulations.
  • Surface restriction shifted the release mechanism towards Fickian behavior.

Conclusions:

  • Theophylline release rate and mechanism from Carbomer matrices can be modulated by adjusting polymer content, diluent selection, and physical matrix constraints.
  • This provides a basis for designing tailored drug delivery systems.

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