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Varicella zoster viral disease.

T J Liesegang1

  • 1Department of Ophthalmology, Mayo Clinic Jacksonville, FL 32224, USA.

Mayo Clinic Proceedings
|August 5, 2000
PubMed
Summary

Herpes zoster, a viral disease, causes significant illness, particularly in older adults. Advances in understanding varicella zoster virus biology and new treatments offer hope for managing acute episodes and preventing future outbreaks.

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Area of Science:

  • Virology
  • Epidemiology
  • Immunology

Background:

  • Herpes zoster (shingles) is a significant cause of morbidity, especially in elderly populations.
  • Ophthalmic zoster presents a particular challenge due to its high incidence and severity.
  • Research into varicella zoster virus (VZV) has improved understanding of disease mechanisms and treatment.

Purpose of the Study:

  • To review the epidemiology, biology, and latency of herpes zoster.
  • To discuss the pathophysiology of herpes zoster and its complications.
  • To outline current and emerging treatment strategies for herpes zoster and postherpetic neuralgia.

Main Methods:

  • Literature review of herpes zoster epidemiology, VZV biology, and pathophysiology.
  • Analysis of current therapeutic interventions, including antivirals and corticosteroids.
  • Evaluation of the impact and potential of the varicella vaccine.

Main Results:

  • Herpes zoster incidence may be slightly higher in females.
  • Ophthalmic zoster is a common and severe manifestation.
  • Effective treatments for acute herpes zoster and postherpetic neuralgia are available.

Conclusions:

  • Continued research enhances the management of herpes zoster.
  • The varicella vaccine shows promise in reducing the future burden of herpes zoster.
  • Comprehensive understanding of VZV is crucial for effective patient care.

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