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[A case of prostatic small cell carcinoma]
Y Hashimoto1, G Kimura, N Tsuboi
1Department of Urology, Nippon Medical School.
Hinyokika Kiyo. Acta Urologica Japonica
|August 10, 2000
Summary
A rare case of advanced prostate cancer presenting with small cell carcinoma and adenocarcinoma was diagnosed. The patient experienced rapid progression and metastasis, leading to a fatal outcome despite investigations.
Area of Science:
- Oncology
- Urology
- Pathology
Background:
- Prostate cancer is a common malignancy in older men.
- Small cell carcinoma of the prostate is a rare and aggressive subtype.
- Metastatic disease significantly impacts prognosis.
Observation:
- A 66-year-old male presented with lumbago and a hard, irregular prostate.
- Elevated prostate-specific antigen (PSA) levels were detected.
- Imaging revealed extensive lymphadenopathy and widespread metastases to the liver and bone.
Findings:
- Histopathology confirmed a mixed histology of small cell carcinoma and adenocarcinoma of the prostate.
- Acute hepatic failure precluded chemotherapy.
- The patient succumbed to the disease within one month of presentation.
Implications:
- This case highlights the aggressive nature of mixed small cell and adenocarcinoma prostate cancer.
- Rapid progression and widespread metastasis underscore the importance of early detection.
- Understanding rare prostate cancer subtypes is crucial for effective management and research.