Related Experiment Video
Updated: Aug 12, 2026

Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
Fibroblast growth factor signalling and cyclin D1 function are necessary for normal mammary gland development during
Abstract:
A number of growth factors, growth factor receptors and cell cycle regulatory proteins have been implicated in the genesis of mammary carcinomas both in animal models as well as in human breast tumour samples. Studies on the development of the mammary gland has revealed that several of the proto-oncogenes, or their closely related gene-family members, have a function in the normal growth and differentiation of the gland. In this review the role of fibroblast growth factor signalling and the critical requirement for the cell cycle regulator, cyclin D1 is discussed with respect to their normal function in mammary gland development and abnormal role in mammary carcinogenesis.
Related Concept Videos
Canonical Wnt Signaling Pathway
Hedgehog Signaling Pathway
Mitogens and the Cell Cycle
TGF - β Signaling Pathway

