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Differences among mechanisms of ribozyme-catalyzed reactions
M Warashina1, Y Takagi, W J Stec
1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo, Japan.
Current Opinion in Biotechnology
|September 7, 2000
Abstract:
The catalytic properties of ribozymes depend on the sophisticated structures of the respective ribozyme-substrate complexes. Although it has been suggested that ribozyme-mediated cleavage of RNA occurs via a rather strictly defined mechanism, recent findings have clearly demonstrated the diversity of reaction mechanisms.