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Interhemispheric asymmetries of the modular structure in human temporal cortex.
R A Galuske1, W Schlote, H Bratzke
1Department of Neurophysiology, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt a.M., Germany. galuske@mpih-frankfurt.mpg.de
Science (New York, N.Y.)
|September 16, 2000
Summary
The left hemisphere
Area of Science:
- Neuroscience
- Auditory Processing
- Brain Lateralization
Background:
- Auditory signal processing for language is lateralized.
- This involves the posterior region of Brodmann area 22.
- Functional lateralization correlates with microcircuitry organization differences.
Purpose of the Study:
- To investigate interhemispheric differences in Brodmann area 22 microcircuitry.
- To explore the relationship between functional and anatomical organization.
- To determine if structural asymmetry underlies functional lateralization in language processing.
Main Methods:
- Neuronal tract tracing was employed.
- Analysis of intrinsic microcircuitry organization in Brodmann area 22.
- Comparison of neuronal cluster spacing and diameter between hemispheres.
Main Results:
- Brodmann area 22 exhibits interhemispheric differences in microcircuitry.
- A modular network of long-range connections links neuronal clusters.
- Neuronal clusters in the left hemisphere are spaced ~20% farther apart than in the right.
Conclusions:
- Structural asymmetries in Brodmann area 22 correlate with functional lateralization.
- The left hemisphere may contain more distinct functional units per area.
- This suggests a greater capacity for specialized language processing in the left hemisphere's area 22.
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