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Constitutive receptor systems for drug discovery

G Chen1, C Jayawickreme, J Way

  • 1Department of Receptor Biochemistry, Glaxo Wellcome Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709, USA.

Journal of Pharmacological and Toxicological Methods
|October 18, 2000
PubMed
Summary

Constitutively active G-protein-coupled receptor systems offer advantages for drug discovery by detecting both agonists and antagonists. These systems show increased sensitivity, particularly for agonist detection, enhancing screening efficiency.

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